Natural and Modified Natural IVF Cycle
Natural and Modified Natural IVF Cycle
In recent years, the effectiveness of in vitro fertilisation has been studied in cases where the use of gonadotropins for ovarian stimulation is either contraindicated or does not produce the desired ovarian response. Natural cycle IVF and modified natural cycle IVF are performed by monitoring the natural ovarian cycle and/or administering very small doses of gonadotropins, with or without the combination of clomiphene citrate (Clomiphene citrate, Serpaphar).
The advantages of this assisted reproduction approach include: no need for injections or, if injections are required, only very small doses of medication are administered; lower medication costs; fewer drug-related side effects; and zero risk of ovarian hyperstimulation syndrome.
The disadvantages of the method include: a reduced probability of fertilisation (possibility of an immature egg, possibility of failure of fertilisation of a mature follicle approximately 20–30%), the possibility of premature ovulation, and the possibility that no egg will be retrieved from the one or two follicles that develop.
Which couples can benefit?
All women who ovulate are suitable candidates for this assisted reproduction method. More specifically, the following may benefit:
- Women with low ovarian reserve whose blood tests show low AMH (Anti-Müllerian Hormone) and high FSH (Follicle Stimulating Hormone)
- Women with a low antral follicle count
- Women who previously had an unsuccessful IVF cycle due to poor response to ovarian stimulation medications (fewer than 3 eggs retrieved)
- Women with a strong family history of breast or ovarian cancer who may choose to avoid hormonal stimulation and follow this method
